Complete reconstitution of the diverse pathways of gentamicin B biosynthesis

Gentamicin B (GB), a valuable starting material for the preparation of the semisynthetic aminoglycoside antibiotic isepamicin, is produced in trace amounts by the wild-type Micromonospora echinospora. While the biosynthetic pathway to GB has remained obscure for decades, we have now identified three...

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Detalles Bibliográficos
Autores principales: Ban, Yeon Hee, Song, Myoung Chong, Hwang, Jae-yeon, Shin, Hea-lyung, Kim, Hak Joong, Hong, Seung Kon, Lee, Na Joon, Park, Je Won, Cha, Sun-Shin, Liu, Hung-wen, Yoon, Yeo Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488028/
https://www.ncbi.nlm.nih.gov/pubmed/30643280
http://dx.doi.org/10.1038/s41589-018-0203-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488028/
https://www.ncbi.nlm.nih.gov/pubmed/30643280
http://dx.doi.org/10.1038/s41589-018-0203-4

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