Predicting synthetic lethal interactions using conserved patterns in protein interaction networks

In response to a need for improved treatments, a number of promising novel targeted cancer therapies are being developed that exploit human synthetic lethal interactions. This is facilitating personalised medicine strategies in cancers where specific tumour suppressors have become inactivated. Mainl...

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Detalles Bibliográficos
Autores principales: Benstead-Hume, Graeme, Chen, Xiangrong, Hopkins, Suzanna R., Lane, Karen A., Downs, Jessica A., Pearl, Frances M. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488098/
https://www.ncbi.nlm.nih.gov/pubmed/30995217
http://dx.doi.org/10.1371/journal.pcbi.1006888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488098/
https://www.ncbi.nlm.nih.gov/pubmed/30995217
http://dx.doi.org/10.1371/journal.pcbi.1006888

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