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Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study

BACKGROUND: Observational studies have shown that excessive dietary fat may be associated with lung carcinogenesis. However, findings from previous studies are inconsistent and it remains unclear whether docosapentaenoic acid (DPA), a kind of polyunsaturated fatty acid, is linked to the risk of lung...

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Autores principales: Liu, Jiaqing, Zhou, Huaqiang, Zhang, Yaxiong, Huang, Yan, Fang, Wenfeng, Yang, Yunpeng, Hong, Shaodong, Chen, Gang, Zhao, Shen, Chen, Xi, Zhang, Zhonghan, Shen, Jiayi, Xian, Wei, Zhan, Jianhua, Zhao, Yuanyuan, Hou, Xue, Ma, Yuxiang, Zhou, Ting, Zhao, Hongyun, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488117/
https://www.ncbi.nlm.nih.gov/pubmed/30741477
http://dx.doi.org/10.1002/cam4.2018
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author Liu, Jiaqing
Zhou, Huaqiang
Zhang, Yaxiong
Huang, Yan
Fang, Wenfeng
Yang, Yunpeng
Hong, Shaodong
Chen, Gang
Zhao, Shen
Chen, Xi
Zhang, Zhonghan
Shen, Jiayi
Xian, Wei
Zhan, Jianhua
Zhao, Yuanyuan
Hou, Xue
Ma, Yuxiang
Zhou, Ting
Zhao, Hongyun
Zhang, Li
author_facet Liu, Jiaqing
Zhou, Huaqiang
Zhang, Yaxiong
Huang, Yan
Fang, Wenfeng
Yang, Yunpeng
Hong, Shaodong
Chen, Gang
Zhao, Shen
Chen, Xi
Zhang, Zhonghan
Shen, Jiayi
Xian, Wei
Zhan, Jianhua
Zhao, Yuanyuan
Hou, Xue
Ma, Yuxiang
Zhou, Ting
Zhao, Hongyun
Zhang, Li
author_sort Liu, Jiaqing
collection PubMed
description BACKGROUND: Observational studies have shown that excessive dietary fat may be associated with lung carcinogenesis. However, findings from previous studies are inconsistent and it remains unclear whether docosapentaenoic acid (DPA), a kind of polyunsaturated fatty acid, is linked to the risk of lung cancer. The aim of this study is to investigate the causal effect of DPA on lung cancer with Mendelian randomization (MR) method. METHODS: With a two‐sample MR approach, we analyzed the summary data from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE, 8866 individuals of European ancestry) Consortium and International Lung Cancer Consortium (ILCCO, 11 348 lung cancer cases and 15 861 controls; European ancestry) to assess the possible causal relationship of DPA on the risk of lung cancer. RESULTS: Our results indicated that genetically predicted higher DPA level has a positive association with lung cancer, where 1% higher DPA was associated with a 2.01‐fold risk of lung cancer (odds ratio [OR]: 2.01, 95% CI = 1.34‐3.01; P = 7.40 × 10(−4)). Additionally, lung cancer was not a causal factor for DPA. The results of MR‐Egger regression analysis showed that there was no evidence for the presence of directional horizontal pleiotropy. CONCLUSIONS: Genetically elevated DPA is positively associated with risk of lung cancer, and more work is needed to investigate the potential mechanisms.
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spelling pubmed-64881172019-05-23 Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study Liu, Jiaqing Zhou, Huaqiang Zhang, Yaxiong Huang, Yan Fang, Wenfeng Yang, Yunpeng Hong, Shaodong Chen, Gang Zhao, Shen Chen, Xi Zhang, Zhonghan Shen, Jiayi Xian, Wei Zhan, Jianhua Zhao, Yuanyuan Hou, Xue Ma, Yuxiang Zhou, Ting Zhao, Hongyun Zhang, Li Cancer Med Cancer Prevention BACKGROUND: Observational studies have shown that excessive dietary fat may be associated with lung carcinogenesis. However, findings from previous studies are inconsistent and it remains unclear whether docosapentaenoic acid (DPA), a kind of polyunsaturated fatty acid, is linked to the risk of lung cancer. The aim of this study is to investigate the causal effect of DPA on lung cancer with Mendelian randomization (MR) method. METHODS: With a two‐sample MR approach, we analyzed the summary data from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE, 8866 individuals of European ancestry) Consortium and International Lung Cancer Consortium (ILCCO, 11 348 lung cancer cases and 15 861 controls; European ancestry) to assess the possible causal relationship of DPA on the risk of lung cancer. RESULTS: Our results indicated that genetically predicted higher DPA level has a positive association with lung cancer, where 1% higher DPA was associated with a 2.01‐fold risk of lung cancer (odds ratio [OR]: 2.01, 95% CI = 1.34‐3.01; P = 7.40 × 10(−4)). Additionally, lung cancer was not a causal factor for DPA. The results of MR‐Egger regression analysis showed that there was no evidence for the presence of directional horizontal pleiotropy. CONCLUSIONS: Genetically elevated DPA is positively associated with risk of lung cancer, and more work is needed to investigate the potential mechanisms. John Wiley and Sons Inc. 2019-02-11 /pmc/articles/PMC6488117/ /pubmed/30741477 http://dx.doi.org/10.1002/cam4.2018 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Liu, Jiaqing
Zhou, Huaqiang
Zhang, Yaxiong
Huang, Yan
Fang, Wenfeng
Yang, Yunpeng
Hong, Shaodong
Chen, Gang
Zhao, Shen
Chen, Xi
Zhang, Zhonghan
Shen, Jiayi
Xian, Wei
Zhan, Jianhua
Zhao, Yuanyuan
Hou, Xue
Ma, Yuxiang
Zhou, Ting
Zhao, Hongyun
Zhang, Li
Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study
title Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study
title_full Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study
title_fullStr Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study
title_full_unstemmed Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study
title_short Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study
title_sort docosapentaenoic acid and lung cancer risk: a mendelian randomization study
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488117/
https://www.ncbi.nlm.nih.gov/pubmed/30741477
http://dx.doi.org/10.1002/cam4.2018
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