CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression

The clinical use of the chemotherapeutic doxorubicin (Dox) is limited by cardiotoxic side-effects. One of the early Dox effects is induction of a sarcoplasmic reticulum (SR) Ca(2+) leak. The chaperone Glucose regulated protein 78 (GRP78) is important for Ca(2+) homeostasis in the endoplasmic reticul...

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Detalles Bibliográficos
Autores principales: Tscheschner, Henrike, Meinhardt, Eric, Schlegel, Philipp, Jungmann, Andreas, Lehmann, Lorenz H., Müller, Oliver J., Most, Patrick, Katus, Hugo A., Raake, Philip W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488194/
https://www.ncbi.nlm.nih.gov/pubmed/31034488
http://dx.doi.org/10.1371/journal.pone.0215992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488194/
https://www.ncbi.nlm.nih.gov/pubmed/31034488
http://dx.doi.org/10.1371/journal.pone.0215992

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