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CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression
The clinical use of the chemotherapeutic doxorubicin (Dox) is limited by cardiotoxic side-effects. One of the early Dox effects is induction of a sarcoplasmic reticulum (SR) Ca(2+) leak. The chaperone Glucose regulated protein 78 (GRP78) is important for Ca(2+) homeostasis in the endoplasmic reticul...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488194/ https://www.ncbi.nlm.nih.gov/pubmed/31034488 http://dx.doi.org/10.1371/journal.pone.0215992 |