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Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling

T cells are thought to discriminate self from foreign peptides by converting small differences in ligand binding half-life into large changes in cell signaling. Such a kinetic proofreading model has been difficult to test directly, as existing methods of altering ligand binding half-life also change...

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Detalles Bibliográficos
Autores principales: Tischer, Doug K, Weiner, Orion David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488292/
https://www.ncbi.nlm.nih.gov/pubmed/30947808
http://dx.doi.org/10.7554/eLife.42498