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Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling
T cells are thought to discriminate self from foreign peptides by converting small differences in ligand binding half-life into large changes in cell signaling. Such a kinetic proofreading model has been difficult to test directly, as existing methods of altering ligand binding half-life also change...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488292/ https://www.ncbi.nlm.nih.gov/pubmed/30947808 http://dx.doi.org/10.7554/eLife.42498 |