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Identification of spatially associated subpopulations by combining scRNA-seq and sequential fluorescence in situ hybridization data

How intrinsic gene-regulatory networks interact with a cell’s spatial environment to define its identity remains poorly understood. Here we present an approach to distinguish intrinsic and extrinsic effects on global gene expression by integrating analysis of sequencing-based and imaging-based singl...

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Detalles Bibliográficos
Autores principales: Zhu, Qian, Shah, Sheel, Dries, Ruben, Cai, Long, Yuan, Guo-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488461/
https://www.ncbi.nlm.nih.gov/pubmed/30371680
http://dx.doi.org/10.1038/nbt.4260