Pharmacokinetic and Pharmacodynamic Properties of a Micro-Dose Nasal Spray Formulation of Desmopressin (AV002) in Healthy Water-Loaded Subjects

PURPOSE: Antidiuretic therapy with desmopressin for nocturia has been hampered by formulations with high doses, low bioavailability and variable pharmacokinetics. AV002 (SER120), a novel, emulsified, microdose desmopressin nasal spray, with a permeation enhancer (cylcopentadecanolide), was developed...

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Detalles Bibliográficos
Autores principales: Andersson, Karl-Erik, Longstreth, James, Brucker, Benjamin M., Campeau, Lysanne, Cheng, Linda, Francis, Leo, Fein, Seymour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488552/
https://www.ncbi.nlm.nih.gov/pubmed/31037429
http://dx.doi.org/10.1007/s11095-019-2628-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488552/
https://www.ncbi.nlm.nih.gov/pubmed/31037429
http://dx.doi.org/10.1007/s11095-019-2628-1

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