Cargando…

UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells

Scaling up blood cell production from hPSCs is critical to advancing hPSC technologies for blood transfusion, immunotherapy, and transplantation. Here we explored the potential of the HSC agonist pyrimido-indole derivative UM171, to expand hematopoietic progenitors (HPs) derived from hPSCs in chemic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mesquitta, Walatta-Tseyon, Wandsnider, Matthew, Kang, HyunJun, Thomson, James, Moskvin, Oleg, Suknuntha, Kran, Slukvin, Igor I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488662/ https://www.ncbi.nlm.nih.gov/pubmed/31036928 http://dx.doi.org/10.1038/s41598-019-43054-4

Ejemplares similares

GATA2 Is Dispensable for Specification of Hemogenic Endothelium but Promotes Endothelial-to-Hematopoietic Transition
por: Kang, HyunJun, et al.
Publicado: (2018)

SOX18-enforced expression diverts hemogenic endothelium-derived progenitors from T towards NK lymphoid pathways
por: Jung, Ho Sun, et al.
Publicado: (2023)

Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells
por: Suknuntha, Kran, et al.
Publicado: (2015)

Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA
por: Brok-Volchanskaya, Vera S., et al.
Publicado: (2019)

Generation of Human Neutrophils from Induced Pluripotent Stem Cells in Chemically Defined Conditions Using ETV2 Modified mRNA
por: Majumder, Aditi, et al.
Publicado: (2020)

Brown-like adipose progenitors derived from human induced pluripotent stem cells: Identification of critical pathways governing their adipogenic capacity
por: Hafner, Anne-Laure, et al.
Publicado: (2016)

Megakaryocytic Expansion in Gilteritinib-Treated Acute Myeloid Leukemia Patients Is Associated With AXL Inhibition
por: Suknuntha, Kran, et al.
Publicado: (2020)

SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis
por: Jung, Ho Sun, et al.
Publicado: (2021)

Improved outcomes of UM171–expanded cord blood transplantation compared with other graft sources: real-world evidence
por: Cohen, Sandra, et al.
Publicado: (2023)

Deciphering the hierarchy of angiohematopoietic progenitors from human pluripotent stem cells
por: Slukvin, Igor I.
Publicado: (2013)

StemRegenin 1 selectively promotes expansion of Multipotent Hematopoietic Progenitors derived from Human Embryonic Stem Cells
por: Tao, Lihong, et al.
Publicado: (2017)

UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells
por: Ngom, Mor, et al.
Publicado: (2018)

CD14(+)/CD31(+) monocytes expanded by UM171 correct hemophilia A in zebrafish upon lentiviral gene transfer of factor VIII
por: Elnaggar, Muhammad, et al.
Publicado: (2022)

UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal
por: Chagraoui, Jalila, et al.
Publicado: (2019)

UM171 cooperates with PIM1 inhibitors to restrict HSC expansion markers and suppress leukemia progression
por: Hu, Anling, et al.
Publicado: (2022)

GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells
por: D'Souza, Saritha S., et al.
Publicado: (2016)

UM171A-induced ROS promote antigen cross-presentation of immunogenic peptides by bone marrow-derived mesenchymal stromal cells
por: Salame, Natasha, et al.
Publicado: (2022)

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells
por: Uenishi, Gene I., et al.
Publicado: (2018)

Leukotriene Receptor Antagonists Inhibit Mitogenic Activity in Triple Negative Breast Cancer Cells
por: Suknuntha, Kran, et al.
Publicado: (2018)

Generation of SIV-resistant T cells and macrophages from nonhuman primate induced pluripotent stem cells with edited CCR5 locus
por: D’Souza, Saritha S., et al.
Publicado: (2022)

The stem cell–supporting small molecule UM171 triggers Cul3-KBTBD4–mediated degradation of ELM2 domain–harboring proteins
por: Žemaitis, Kristijonas, et al.
Publicado: (2023)

At PS171 (ASTERIX)
Publicado: (1983)

Neonatal Hepatic Myeloid Progenitors Expand and Propagate Liver Injury in Mice
por: Alkhani, Anas, et al.
Publicado: (2023)

Premyogenic progenitors derived from human pluripotent stem cells expand in floating culture and differentiate into transplantable myogenic progenitors
por: Sakai-Takemura, Fusako, et al.
Publicado: (2018)

Altered Erythro-Myeloid Progenitor Cells Are Highly Expanded in Intensively Regenerating Hematopoiesis
por: Faltusová, Kateřina, et al.
Publicado: (2020)

Specification and Diversification of Pericytes and Smooth Muscle Cells from Mesenchymoangioblasts
por: Kumar, Akhilesh, et al.
Publicado: (2017)

Allogeneic MHC-matched T-cell receptor α/β-depleted bone marrow transplants in SHIV-infected, ART-suppressed Mauritian cynomolgus macaques
por: Weinfurter, Jason T., et al.
Publicado: (2022)

171th RB Meeting
Publicado: (2005)

Memorandum: PS171 experiment
por: Klempt, E
Publicado: (1982)

In Freiburg, um Freiburg, um Freiburg herum /
por: Meckel, Eberhard, 1907-1969
Publicado: (1957)

Commitment of Common T/Natural Killer (Nk) Progenitors to Unipotent T and Nk Progenitors in the Murine Fetal Thymus Revealed by a Single Progenitor Assay
por: Ikawa, Tomokatsu, et al.
Publicado: (1999)

Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells
por: Kumar, Nathan, et al.
Publicado: (2015)

Um Achado Acidental de um Sarcoma Cardíaco
por: Santos, Rita Reis, et al.
Publicado: (2022)

Um Subtipo Raro de um Tumor Raro
por: Medeiros, Paulo, et al.
Publicado: (2023)

Health Tract, No. 171: Great Eaters
Publicado: (1863)

Health Tract, No. 171: Great Eaters
Publicado: (1865)

Qualquer um
por: Suttana, Renato
Publicado: (2010)

Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells
por: Ohmine, Seiga, et al.
Publicado: (2011)

Good manufacturing practice production of CD34(+) progenitor-derived NK cells for adoptive immunotherapy in acute myeloid leukemia
por: de Jonge, P. K. J. D., et al.
Publicado: (2023)

171st Symposium of the International Astronomical Union
por: Bender, Ralph, et al.
Publicado: (1996)

Cannot write session to /tmp/vufind_sessions/sess_1jblf9icfpmrhsivbbjmta6d45