Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure

Cardiomyocyte-specific increases in phosphorylated Hsp20 (S16D-Hsp20) to levels similar to those observed in human failing hearts are associated with early fibrotic remodeling and depressed left ventricular function, symptoms which progress to heart failure and early death. The underlying mechanisms...

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Detalles Bibliográficos
Autores principales: Gardner, George T., Travers, Joshua G., Qian, Jiang, Liu, Guan-Sheng, Haghighi, Kobra, Robbins, Nathan, Jiang, Min, Li, Yutian, Fan, Guo-Chang, Rubinstein, Jack, Blaxall, Burns C., Kranias, Evangelia G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488766/
https://www.ncbi.nlm.nih.gov/pubmed/31061921
http://dx.doi.org/10.1016/j.jacbts.2018.11.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488766/
https://www.ncbi.nlm.nih.gov/pubmed/31061921
http://dx.doi.org/10.1016/j.jacbts.2018.11.007

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