How many samples are needed to infer truly clonal mutations from heterogenous tumours?

BACKGROUND: Modern cancer treatment strategies aim to target tumour specific genetic (or epigenetic) alterations. Treatment response improves if these alterations are clonal, i.e. present in all cancer cells within tumours. However, the identification of truly clonal alterations is impaired by the t...

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Detalles Bibliográficos
Autores principales: Opasic, Luka, Zhou, Da, Werner, Benjamin, Dingli, David, Traulsen, Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489174/
https://www.ncbi.nlm.nih.gov/pubmed/31035962
http://dx.doi.org/10.1186/s12885-019-5597-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489174/
https://www.ncbi.nlm.nih.gov/pubmed/31035962
http://dx.doi.org/10.1186/s12885-019-5597-1

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