Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport

Mutations in the microtubule-associated protein tau (MAPT) underlie multiple neurodegenerative disorders, yet the pathophysiological mechanisms are unclear. A novel variant in MAPT resulting in an alanine to threonine substitution at position 152 (A152T tau) has recently been described as a signific...

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Detalles Bibliográficos
Autores principales: Butler, Victoria J, Salazar, Dominique A, Soriano-Castell, David, Alves-Ferreira, Miguel, Dennissen, Frank J A, Vohra, Mihir, Oses-Prieto, Juan A, Li, Kathy H, Wang, Austin L, Jing, Beibei, Li, Biao, Groisman, Alex, Gutierrez, Edgar, Mooney, Sean, Burlingame, Alma L, Ashrafi, Kaveh, Mandelkow, Eva-Maria, Encalada, Sandra E, Kao, Aimee W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489414/
https://www.ncbi.nlm.nih.gov/pubmed/30590647
http://dx.doi.org/10.1093/hmg/ddy442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489414/
https://www.ncbi.nlm.nih.gov/pubmed/30590647
http://dx.doi.org/10.1093/hmg/ddy442

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