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The biosynthetic pathway to ossamycin, a macrocyclic polyketide bearing a spiroacetal moiety

Ossamycin from Streptomyces hygroscopicus var. ossamyceticus is an antifungal and cytotoxic polyketide and a potent inhibitor of the mitochondrial ATPase. Analysis of a near-complete genome sequence of the ossamycin producer has allowed the identification of the 127-kbp ossamycin biosynthetic gene c...

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Detalles Bibliográficos
Autores principales: Bilyk, Oksana, Samborskyy, Markiyan, Leadlay, Peter F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490886/
https://www.ncbi.nlm.nih.gov/pubmed/31039188
http://dx.doi.org/10.1371/journal.pone.0215958