Allele-specific enhancers mediate associations between LCAT and ABCA1 polymorphisms and HDL metabolism

For most complex traits, the majority of SNPs identified through genome-wide association studies (GWAS) reside within noncoding regions that have no known function. However, these regions are enriched for the regulatory enhancers specific to the cells relevant to the specific trait. Indeed, many of...

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Detalles Bibliográficos
Autores principales: Howard, Alicia D., Wang, Xiaochun, Prasad, Megana, Sahu, Avinash Das, Aniba, Radhouane, Miller, Michael, Hannenhalli, Sridhar, Chang, Yen-Pei Christy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490890/
https://www.ncbi.nlm.nih.gov/pubmed/31039173
http://dx.doi.org/10.1371/journal.pone.0215911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490890/
https://www.ncbi.nlm.nih.gov/pubmed/31039173
http://dx.doi.org/10.1371/journal.pone.0215911

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