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Allele-specific enhancers mediate associations between LCAT and ABCA1 polymorphisms and HDL metabolism
For most complex traits, the majority of SNPs identified through genome-wide association studies (GWAS) reside within noncoding regions that have no known function. However, these regions are enriched for the regulatory enhancers specific to the cells relevant to the specific trait. Indeed, many of...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490890/ https://www.ncbi.nlm.nih.gov/pubmed/31039173 http://dx.doi.org/10.1371/journal.pone.0215911 |