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Early existence and biochemical evolution characterise acutely synaptotoxic PrP(Sc)
Although considerable evidence supports that misfolded prion protein (PrP(Sc)) is the principal component of “prions”, underpinning both transmissibility and neurotoxicity, clear consensus around a number of fundamental aspects of pathogenesis has not been achieved, including the time of appearance...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490942/ https://www.ncbi.nlm.nih.gov/pubmed/30970042 http://dx.doi.org/10.1371/journal.ppat.1007712 |