New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis

BACKGROUND: Noonan syndrome (NS) is a genetic disorder characterized by short stature, a distinctive facial appearance, and heart defects. We recently discovered a novel NS gene, RIT1, which is a member of the RAS subfamily of small GTPases. NS patients with RIT1 mutations have a high incidence of h...

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Detalles Bibliográficos
Autores principales: Takahara, Shingo, Inoue, Shin-ichi, Miyagawa-Tomita, Sachiko, Matsuura, Katsuhisa, Nakashima, Yasumi, Niihori, Tetsuya, Matsubara, Yoichi, Saiki, Yoshikatsu, Aoki, Yoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491386/
https://www.ncbi.nlm.nih.gov/pubmed/30898653
http://dx.doi.org/10.1016/j.ebiom.2019.03.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491386/
https://www.ncbi.nlm.nih.gov/pubmed/30898653
http://dx.doi.org/10.1016/j.ebiom.2019.03.014

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