Re-interpretation of PAM50 gene expression as quantitative tumor dimensions shows utility for clinical trials: application to prognosis and response to paclitaxel in breast cancer

BACKGROUND: We recently showed PAM50 gene expression data can be represented by five quantitative, orthogonal, multi-gene breast tumor traits. These novel tumor ‘dimensions’ were superior to categorical intrinsic subtypes for clustering in high-risk breast cancer pedigrees, indicating potential to r...

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Detalles Bibliográficos
Autores principales: Camp, Nicola J., Madsen, Michael J., Herranz, Jesús, Rodríguez-Lescure, Álvaro, Ruiz, Amparo, Martín, Miguel, Bernard, Philip S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Clinical Trial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491406/
https://www.ncbi.nlm.nih.gov/pubmed/30673970
http://dx.doi.org/10.1007/s10549-018-05097-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491406/
https://www.ncbi.nlm.nih.gov/pubmed/30673970
http://dx.doi.org/10.1007/s10549-018-05097-5

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