The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

Lysosomal replacement enzymes are essential therapeutic options for rare congenital lysosomal enzyme deficiencies, but enzymes in clinical use are only partially effective due to short circulatory half-life and inefficient biodistribution. Replacement enzymes are primarily taken up by cell surface g...

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Detalles Bibliográficos
Autores principales: Tian, Weihua, Ye, Zilu, Wang, Shengjun, Schulz, Morten Alder, Van Coillie, Julie, Sun, Lingbo, Chen, Yen-Hsi, Narimatsu, Yoshiki, Hansen, Lars, Kristensen, Claus, Mandel, Ulla, Bennett, Eric Paul, Jabbarzadeh-Tabrizi, Siamak, Schiffmann, Raphael, Shen, Jin-Song, Vakhrushev, Sergey Y., Clausen, Henrik, Yang, Zhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491494/
https://www.ncbi.nlm.nih.gov/pubmed/31040271
http://dx.doi.org/10.1038/s41467-019-09809-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491494/
https://www.ncbi.nlm.nih.gov/pubmed/31040271
http://dx.doi.org/10.1038/s41467-019-09809-3

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