Off-Label Use of Bumetanide for Brain Disorders: An Overview

Bumetanide (BTN or BUM) is a FDA-approved potent loop diuretic (LD) that acts by antagonizing sodium-potassium-chloride (Na-K-Cl) cotransporters, NKCC1 (SLc12a2) and NKCC2. While NKCC1 is expressed both in the CNS and in systemic organs, NKCC2 is kidney-specific. The off-label use of BTN to modulate...

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Detalles Bibliográficos
Autores principales: Kharod, Shivani C., Kang, Seok Kyu, Kadam, Shilpa D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491514/
https://www.ncbi.nlm.nih.gov/pubmed/31068771
http://dx.doi.org/10.3389/fnins.2019.00310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491514/
https://www.ncbi.nlm.nih.gov/pubmed/31068771
http://dx.doi.org/10.3389/fnins.2019.00310

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