SOD1-positive aggregate accumulation in the CNS predicts slower disease progression and increased longevity in a mutant SOD1 mouse model of ALS

Non-natively folded variants of superoxide dismutase 1 (SOD1) are thought to contribute to the pathogenesis of familial amyotrophic lateral sclerosis (ALS), however the relative toxicities of these variants are controversial. Here, we aimed to decipher the relationships between the different SOD1 va...

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Detalles Bibliográficos
Autores principales: Gill, Cindy, Phelan, James P., Hatzipetros, Theo, Kidd, Joshua D., Tassinari, Valerie R., Levine, Beth, Wang, Monica Z., Moreno, Andrew, Thompson, Kenneth, Maier, Marcel, Grimm, Jan, Gill, Alan, Vieira, Fernando G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491559/
https://www.ncbi.nlm.nih.gov/pubmed/31040321
http://dx.doi.org/10.1038/s41598-019-43164-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491559/
https://www.ncbi.nlm.nih.gov/pubmed/31040321
http://dx.doi.org/10.1038/s41598-019-43164-z

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