Characterization of the Phosphorylation Site of GRTH/DDX25 and Protein Kinase A Binding Interface Provides Structural Basis for the Design of a Non-Hormonal Male Contraceptive

Gonadotropin Regulated Testicular Helicase (GRTH/DDX25), expressed in the male gonad, is essential for the completion of spermatogenesis. Our early studies revealed a missense mutation (R242H) of GRTH in 5.8% of Japanese patient population with azoospermia. Transfection of the mutant GRTH construct...

Descripción completa

Detalles Bibliográficos
Autores principales: Raju, Murugananthkumar, Hassan, Sergio A., Kavarthapu, Raghuveer, Anbazhagan, Rajakumar, Dufau, Maria L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491591/
https://www.ncbi.nlm.nih.gov/pubmed/31040297
http://dx.doi.org/10.1038/s41598-019-42857-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491591/
https://www.ncbi.nlm.nih.gov/pubmed/31040297
http://dx.doi.org/10.1038/s41598-019-42857-9

Ejemplares similares