Estimating parameters of nonlinear dynamic systems in pharmacology using chaos synchronization and grid search

Bridging fundamental approaches to model optimization for pharmacometricians, systems pharmacologists and statisticians is a critical issue. These fields rely primarily on Maximum Likelihood and Extended Least Squares metrics with iterative estimation of parameters. Our research combines adaptive ch...

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Detalles Bibliográficos
Autores principales: Pillai, Nikhil, Schwartz, Sorell L., Ho, Thang, Dokoumetzidis, Aris, Bies, Robert, Freedman, Immanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491657/
https://www.ncbi.nlm.nih.gov/pubmed/30929120
http://dx.doi.org/10.1007/s10928-019-09629-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491657/
https://www.ncbi.nlm.nih.gov/pubmed/30929120
http://dx.doi.org/10.1007/s10928-019-09629-4

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