Supraspinal and Peripheral, but Not Intrathecal, σ(1)R Blockade by S1RA Enhances Morphine Antinociception

Sigma-1 receptor (σ(1)R) antagonism increases the effects of morphine on acute nociceptive pain. S1RA (E-52862) is a selective σ(1)R antagonist widely used to study the role of σ(1)Rs. S1RA alone exerted antinociceptive effect in the formalin test in rats and increased noradrenaline levels in the sp...

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Detalles Bibliográficos
Autores principales: Vidal-Torres, Alba, Fernández-Pastor, Begoña, Carceller, Alicia, Vela, José Miguel, Merlos, Manuel, Zamanillo, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491787/
https://www.ncbi.nlm.nih.gov/pubmed/31068818
http://dx.doi.org/10.3389/fphar.2019.00422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491787/
https://www.ncbi.nlm.nih.gov/pubmed/31068818
http://dx.doi.org/10.3389/fphar.2019.00422

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