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Supraspinal and Peripheral, but Not Intrathecal, σ(1)R Blockade by S1RA Enhances Morphine Antinociception
Sigma-1 receptor (σ(1)R) antagonism increases the effects of morphine on acute nociceptive pain. S1RA (E-52862) is a selective σ(1)R antagonist widely used to study the role of σ(1)Rs. S1RA alone exerted antinociceptive effect in the formalin test in rats and increased noradrenaline levels in the sp...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491787/ https://www.ncbi.nlm.nih.gov/pubmed/31068818 http://dx.doi.org/10.3389/fphar.2019.00422 |