An Activity‐Based Probe Targeting Non‐Catalytic, Highly Conserved Amino Acid Residues within Bromodomains

Bromodomain‐containing proteins are epigenetic modulators involved in a wide range of cellular processes, from recruitment of transcription factors to pathological disruption of gene regulation and cancer development. Since the druggability of these acetyl‐lysine reader domains was established, effo...

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Detalles Bibliográficos
Autores principales: D'Ascenzio, Melissa, Pugh, Kathryn M., Konietzny, Rebecca, Berridge, Georgina, Tallant, Cynthia, Hashem, Shaima, Monteiro, Octovia, Thomas, Jason R., Schirle, Markus, Knapp, Stefan, Marsden, Brian, Fedorov, Oleg, Bountra, Chas, Kessler, Benedikt M., Brennan, Paul E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492141/
https://www.ncbi.nlm.nih.gov/pubmed/30589164
http://dx.doi.org/10.1002/anie.201807825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492141/
https://www.ncbi.nlm.nih.gov/pubmed/30589164
http://dx.doi.org/10.1002/anie.201807825

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