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IgG4 drives M2a macrophages to a regulatory M2b‐like phenotype: potential implication in immune tolerance

BACKGROUND: Macrophages can be converted in vitro into immunoregulatory M2b macrophages in the presence of immune complexes (ICs), but the role of the specific subclasses IgG1 or IgG4 in this phenotypic and functional change is not known. OBJECTIVE: We aimed to refine the original method by applying...

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Detalles Bibliográficos
Autores principales: Bianchini, Rodolfo, Roth‐Walter, Franziska, Ohradanova‐Repic, Anna, Flicker, Sabine, Hufnagl, Karin, Fischer, Michael Bernhard, Stockinger, Hannes, Jensen‐Jarolim, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492166/
https://www.ncbi.nlm.nih.gov/pubmed/30338531
http://dx.doi.org/10.1111/all.13635