Optogenetic control of iPS cell‐derived neurons in 2D and 3D culture systems using channelrhodopsin‐2 expression driven by the synapsin‐1 and calcium‐calmodulin kinase II promoters

Development of an optogenetically controllable human neural network model in three‐dimensional (3D) cultures can provide an investigative system that is more physiologically relevant and better able to mimic aspects of human brain function. Light‐sensitive neurons were generated by transducing chann...

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Detalles Bibliográficos
Autores principales: Lee, Si‐Yuen, George, Julian H., Nagel, David A., Ye, Hua, Kueberuwa, Gray, Seymour, Leonard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492196/
https://www.ncbi.nlm.nih.gov/pubmed/30550638
http://dx.doi.org/10.1002/term.2786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492196/
https://www.ncbi.nlm.nih.gov/pubmed/30550638
http://dx.doi.org/10.1002/term.2786

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