Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention

Vascular tumors are neoplasms of endothelial cells, a significant number of which present in childhood. Recent studies have examined the mutational landscape of many subtypes of vascular tumors, identifying mutations primarily within the Ras–mitogen-activated protein kinase (MAPK) pathway and provid...

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Detalles Bibliográficos
Autores principales: Cheraghlou, Shayan, Lim, Young, Choate, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492225/
https://www.ncbi.nlm.nih.gov/pubmed/31069062
http://dx.doi.org/10.12688/f1000research.16160.1
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author Cheraghlou, Shayan
Lim, Young
Choate, Keith
author_facet Cheraghlou, Shayan
Lim, Young
Choate, Keith
author_sort Cheraghlou, Shayan
collection PubMed
description Vascular tumors are neoplasms of endothelial cells, a significant number of which present in childhood. Recent studies have examined the mutational landscape of many subtypes of vascular tumors, identifying mutations primarily within the Ras–mitogen-activated protein kinase (MAPK) pathway and providing a unique opportunity to consider targeted therapeutics. This review will summarize the current understanding of childhood vascular tumor pathobiology.
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spelling pubmed-64922252019-05-07 Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention Cheraghlou, Shayan Lim, Young Choate, Keith F1000Res Review Vascular tumors are neoplasms of endothelial cells, a significant number of which present in childhood. Recent studies have examined the mutational landscape of many subtypes of vascular tumors, identifying mutations primarily within the Ras–mitogen-activated protein kinase (MAPK) pathway and providing a unique opportunity to consider targeted therapeutics. This review will summarize the current understanding of childhood vascular tumor pathobiology. F1000 Research Limited 2019-04-30 /pmc/articles/PMC6492225/ /pubmed/31069062 http://dx.doi.org/10.12688/f1000research.16160.1 Text en Copyright: © 2019 Cheraghlou S et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Cheraghlou, Shayan
Lim, Young
Choate, Keith
Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention
title Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention
title_full Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention
title_fullStr Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention
title_full_unstemmed Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention
title_short Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention
title_sort genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492225/
https://www.ncbi.nlm.nih.gov/pubmed/31069062
http://dx.doi.org/10.12688/f1000research.16160.1
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AT choatekeith geneticinvestigationofchildhoodvasculartumorbiologyrevealspathwaysfortherapeuticintervention

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