(19)F Dark-State Exchange Saturation Transfer NMR Reveals Reversible Formation of Protein-Specific Large Clusters in High-Concentration Protein Mixtures

[Image: see text] Proteins frequently exist as high-concentration mixtures, both in biological environments and increasingly in biopharmaceutical co-formulations. Such crowded conditions promote protein–protein interactions, potentially leading to formation of protein clusters, aggregation, and phas...

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Detalles Bibliográficos
Autores principales: Edwards, John M., Bramham, Jack E., Podmore, Adrian, Bishop, Steven M., van der Walle, Christopher F., Golovanov, Alexander P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492951/
https://www.ncbi.nlm.nih.gov/pubmed/30801173
http://dx.doi.org/10.1021/acs.analchem.9b00143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492951/
https://www.ncbi.nlm.nih.gov/pubmed/30801173
http://dx.doi.org/10.1021/acs.analchem.9b00143

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