T cell repertoire to citrullinated self-peptides in healthy humans is not confined to the HLA-DR SE alleles; Targeting of citrullinated self-peptides presented by HLA-DP4 for tumour therapy

Post-translational modifications are induced in stressed cells which cause them to be recognised by the system. One such modification is citrullination where the positive charged arginine is modified to a neutral citrulline. We demonstrate most healthy donors show an oligoclonal CD4 response in vitr...

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Detalles Bibliográficos
Autores principales: Brentville, Victoria A, Symonds, Peter, Cook, Katherine W, Daniels, Ian, Pitt, Tracy, Gijon, Mohamed, Vaghela, Poonam, Xue, Wei, Shah, Sabaria, Metheringham, Rachael L, Durrant, Lindy G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492960/
https://www.ncbi.nlm.nih.gov/pubmed/31069134
http://dx.doi.org/10.1080/2162402X.2019.1576490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492960/
https://www.ncbi.nlm.nih.gov/pubmed/31069134
http://dx.doi.org/10.1080/2162402X.2019.1576490

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