E6 proteins from high-risk HPV, low-risk HPV, and animal papillomaviruses activate the Wnt/β-catenin pathway through E6AP-dependent degradation of NHERF1

High-risk human papillomavirus (HPV) E6 proteins associate with the cellular ubiquitin ligase E6-Associated Protein (E6AP), and then recruit both p53 and certain cellular PDZ proteins for ubiquitination and degradation by the proteasome. Low-risk HPV E6 proteins also associate with E6AP, yet fail to...

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Detalles Bibliográficos
Autores principales: Drews, Camille M., Case, Samuel, Vande Pol, Scott B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493770/
https://www.ncbi.nlm.nih.gov/pubmed/31002735
http://dx.doi.org/10.1371/journal.ppat.1007575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493770/
https://www.ncbi.nlm.nih.gov/pubmed/31002735
http://dx.doi.org/10.1371/journal.ppat.1007575

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