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Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria
Staphylococcus aureus and other bacterial pathogens affix wall teichoic acids (WTAs) to their surface. These highly abundant anionic glycopolymers have critical functions in bacterial physiology and their susceptibility to β-lactam antibiotics. The membrane-associated TagA glycosyltransferase (GT) c...
Autores principales: | Kattke, Michele D., Gosschalk, Jason E., Martinez, Orlando E., Kumar, Garima, Gale, Robert T., Cascio, Duilio, Sawaya, Michael R., Philips, Martin, Brown, Eric D., Clubb, Robert T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493773/ https://www.ncbi.nlm.nih.gov/pubmed/31002736 http://dx.doi.org/10.1371/journal.ppat.1007723 |
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