Synthesis and Biological Evaluation of (E)-4-Hydroxy-3-methylbut-2-enyl Phosphate (HMBP) Aryloxy Triester Phosphoramidate Prodrugs as Activators of Vγ9/Vδ2 T-Cell Immune Responses

[Image: see text] The aryloxy triester phosphoramidate prodrug approach has been used with success in drug discovery. Herein, we describe the first application of this prodrug technology to the monophosphate derivative of the phosphoantigen HMBPP and one of its analogues. Some of these prodrugs exhi...

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Detalles Bibliográficos
Autores principales: Davey, Martin S., Malde, Roshni, Mykura, Rory C., Baker, Alfie T., Taher, Taher E., Le Duff, Cécile S., Willcox, Benjamin E., Mehellou, Youcef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493972/
https://www.ncbi.nlm.nih.gov/pubmed/29457898
http://dx.doi.org/10.1021/acs.jmedchem.7b01824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493972/
https://www.ncbi.nlm.nih.gov/pubmed/29457898
http://dx.doi.org/10.1021/acs.jmedchem.7b01824

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