IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

Autophagy plays a broad role in health and disease. Here, we show that inositol polyphosphate multikinase (IPMK) is a prominent physiological determinant of autophagy and is critical for liver inflammation and regeneration. Deletion of IPMK diminishes autophagy in cell lines and mouse liver. Regulat...

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Detalles Bibliográficos
Autores principales: Guha, Prasun, Tyagi, Richa, Chowdhury, Sayan, Reilly, Luke, Fu, Chenglai, Xu, Risheng, Resnick, Adam C., Snyder, Solomon H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494083/
https://www.ncbi.nlm.nih.gov/pubmed/30840891
http://dx.doi.org/10.1016/j.celrep.2019.02.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494083/
https://www.ncbi.nlm.nih.gov/pubmed/30840891
http://dx.doi.org/10.1016/j.celrep.2019.02.013

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