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p63 establishes epithelial enhancers at critical craniofacial development genes

The transcription factor p63 is a key mediator of epidermal development. Point mutations in p63 in patients lead to developmental defects, including orofacial clefting. To date, knowledge on how pivotal the role of p63 is in human craniofacial development is limited. Using an inducible transdifferen...

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Detalles Bibliográficos
Autores principales: Lin-Shiao, Enrique, Lan, Yemin, Welzenbach, Julia, Alexander, Katherine A., Zhang, Zhen, Knapp, Michael, Mangold, Elisabeth, Sammons, Morgan, Ludwig, Kerstin U., Berger, Shelley L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494499/
https://www.ncbi.nlm.nih.gov/pubmed/31049400
http://dx.doi.org/10.1126/sciadv.aaw0946