Downregulation of thromboxane A2 and angiotensin II type 1 receptors associated with aging-related decrease in internal anal sphincter tone

Aging-associated decrease in internal anal sphincter (IAS) tone (AADI) is a major contributor in the rectoanal incontinence (RI). To determine the pathogenesis of AADI, we investigated the effect of aging on GPCR activation and related downstream signaling. We particularly investigated two GPCRs tha...

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Detalles Bibliográficos
Autores principales: Mohanty, Ipsita, Singh, Jagmohan, Rattan, Satish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494869/
https://www.ncbi.nlm.nih.gov/pubmed/31043680
http://dx.doi.org/10.1038/s41598-019-42894-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494869/
https://www.ncbi.nlm.nih.gov/pubmed/31043680
http://dx.doi.org/10.1038/s41598-019-42894-4

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