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Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands
Acid-sensing ion channels (ASICs) belong to the degenerin/epithelial sodium channel protein family that form mechanosensitive ion channels. Evidence as to whether or not ASICs activity is directly modulated by mechanical force is lacking. Human ASICs (hASIC1(V3), hASIC2a and hASIC3a) were heterologo...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494901/ https://www.ncbi.nlm.nih.gov/pubmed/31043630 http://dx.doi.org/10.1038/s41598-019-43097-7 |