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The cell adhesion protein CAR is a negative regulator of synaptic transmission

The Coxsackievirus and adenovirus receptor (CAR) is essential for normal electrical conductance in the heart, but its role in the postnatal brain is largely unknown. Using brain specific CAR knockout mice (KO), we discovered an unexpected role of CAR in neuronal communication. This includes increase...

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Detalles Bibliográficos
Autores principales: Wrackmeyer, Uta, Kaldrack, Joanna, Jüttner, René, Pannasch, Ulrike, Gimber, Niclas, Freiberg, Fabian, Purfürst, Bettina, Kainmueller, Dagmar, Schmitz, Dietmar, Haucke, Volker, Rathjen, Fritz G., Gotthardt, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494904/
https://www.ncbi.nlm.nih.gov/pubmed/31043663
http://dx.doi.org/10.1038/s41598-019-43150-5