Cargando…

The cell adhesion protein CAR is a negative regulator of synaptic transmission

The Coxsackievirus and adenovirus receptor (CAR) is essential for normal electrical conductance in the heart, but its role in the postnatal brain is largely unknown. Using brain specific CAR knockout mice (KO), we discovered an unexpected role of CAR in neuronal communication. This includes increase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wrackmeyer, Uta, Kaldrack, Joanna, Jüttner, René, Pannasch, Ulrike, Gimber, Niclas, Freiberg, Fabian, Purfürst, Bettina, Kainmueller, Dagmar, Schmitz, Dietmar, Haucke, Volker, Rathjen, Fritz G., Gotthardt, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494904/ https://www.ncbi.nlm.nih.gov/pubmed/31043663 http://dx.doi.org/10.1038/s41598-019-43150-5

Ejemplares similares

The tight junction protein CAR regulates cardiac conduction and cell–cell communication
por: Lisewski, Ulrike, et al.
Publicado: (2008)

Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins
por: Gimber, Niclas, et al.
Publicado: (2015)

The IgCAM CAR Regulates Gap Junction-Mediated Coupling on Embryonic Cardiomyocytes and Affects Their Beating Frequency
por: Matthaeus, Claudia, et al.
Publicado: (2022)

The IgSF Cell Adhesion Protein CLMP and Congenital Short Bowel Syndrome (CSBS)
por: Rathjen, Fritz G., et al.
Publicado: (2023)

The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in mice
por: Langhorst, Hanna, et al.
Publicado: (2018)

The synaptic scaffold protein MPP2 interacts with GABA(A) receptors at the periphery of the postsynaptic density of glutamatergic synapses
por: Schmerl, Bettina, et al.
Publicado: (2022)

CAR links hypoxia signaling to improved survival after myocardial infarction
por: Freiberg, Fabian, et al.
Publicado: (2023)

Synapse Geometry and Receptor Dynamics Modulate Synaptic Strength
por: Freche, Dominik, et al.
Publicado: (2011)

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices
por: Pannasch, Ulrike, et al.
Publicado: (2012)

RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses
por: Brockmann, Marisa M, et al.
Publicado: (2019)

Ryanodine Receptor Activation Induces Long-Term Plasticity of Spine Calcium Dynamics
por: Johenning, Friedrich W., et al.
Publicado: (2015)

Simultaneous Multicolor DNA-PAINT without Sequential Fluid Exchange Using Spectral Demixing
por: Gimber, Niclas, et al.
Publicado: (2022)

Retinal pigment epithelium protein of 65 kDA gene-linked retinal degeneration is not modulated by chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C/ chondroitin sulfate proteoglycan 5
por: Cottet, Sandra, et al.
Publicado: (2013)

The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord
por: Schmidt, Hannes, et al.
Publicado: (2007)

C-type natriuretic peptide is a bifurcation factor for sensory neurons
por: Schmidt, Hannes, et al.
Publicado: (2009)

Endosomal phosphatidylinositol 3‐phosphate controls synaptic vesicle cycling and neurotransmission
por: Liu, Guan‐Ting, et al.
Publicado: (2022)

Overlapping functions of stonin 2 and SV2 in sorting of the calcium sensor synaptotagmin 1 to synaptic vesicles
por: Kaempf, Natalie, et al.
Publicado: (2015)

ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Iγ
por: Krauss, Michael, et al.
Publicado: (2003)

Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses
por: Maglione, Marta, et al.
Publicado: (2019)

Automated Detection and Localization of Synaptic Vesicles in Electron Microscopy Images
por: Imbrosci, Barbara, et al.
Publicado: (2022)

Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2
por: Jung, Nadja, et al.
Publicado: (2007)

Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced behavioral changes in the open maze, water maze and resident intruder test
por: Montag, Dirk, et al.
Publicado: (2023)

Splice-Site Mutations Cause Rrp6-Mediated Nuclear Retention of the Unspliced RNAs and Transcriptional Down-Regulation of the Splicing-Defective Genes
por: Eberle, Andrea B., et al.
Publicado: (2010)

Astroglial gap junctions shape neuronal network activity
por: Pannasch, Ulrike, et al.
Publicado: (2012)

Astroglial Cx30 sustains neuronal population bursts independently of gap‐junction mediated biochemical coupling
por: Pannasch, Ulrike, et al.
Publicado: (2019)

Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum
por: Kuijpers, Marijn, et al.
Publicado: (2022)

Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum
por: Kuijpers, Marijn, et al.
Publicado: (2021)

Evaluation of Static Autonomous GNSS Positioning Accuracy Using Single-, Dual-, and Tri-Frequency Smartphones in Forest Canopy Environments
por: Purfürst, Thomas
Publicado: (2022)

Lipids, GTPases, and their regulators in membrane dynamics: an intracellular ménage à trois
por: Echard, Arnaud, et al.
Publicado: (2015)

Inositol Triphosphate Signaling Triggers Lysosome Biogenesis Via Calcium Release from Endoplasmic Reticulum Stores
por: Malek, Mouhannad, et al.
Publicado: (2022)

Early Days of Tenascin-R Research: Two Approaches Discovered and Shed Light on Tenascin-R
por: Rathjen, Fritz G., et al.
Publicado: (2021)

Cell-specific synaptic plasticity induced by network oscillations
por: Zarnadze, Shota, et al.
Publicado: (2016)

Optogenetic Acidification of Synaptic Vesicles and Lysosomes
por: Rost, Benjamin R., et al.
Publicado: (2015)

Ahnak1 abnormally localizes in muscular dystrophies and contributes to muscle vesicle release
por: Zacharias, Ute, et al.
Publicado: (2011)

STATs in NK-Cells: The Good, the Bad, and the Ugly
por: Gotthardt, Dagmar, et al.
Publicado: (2017)

Group II Metabotropic Glutamate Receptors Depress Synaptic Transmission onto Subicular Burst Firing Neurons
por: Kintscher, Michael, et al.
Publicado: (2012)

Orchestrating vesicular and nonvesicular membrane dynamics by intrinsically disordered proteins
por: Sigrist, Stephan J, et al.
Publicado: (2023)

Species-specific differences in synaptic transmission and plasticity
por: Beed, Prateep, et al.
Publicado: (2020)

Elongator function in tRNA wobble uridine modification is conserved between yeast and plants
por: Mehlgarten, Constance, et al.
Publicado: (2010)

Real-World Outcome in the pre-CAR-T Era of Myeloma Patients Qualifying for CAR-T Cell Therapy
por: Brechbühl, Simon, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mqun3r8nc8rd1aogukc03ngl8u