Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis

MicroRNAs (miRNAs) act as regulators of aging at the tissue or organism level or as regulators of cellular senescence. Targeted deletion of miR-126 in mice causes partial embryonic lethality, but its biological function in the liver is still largely unknown. Here, we deleted miR-126a, using the CRIS...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Yi, Qin, Dan, Hu, Bian, Zhang, Chunjing, Liu, Shenghui, Wu, Dongde, Huang, Wendong, Huang, Xingxu, Wang, Liqiang, Chen, Xiangmei, Zhang, Lisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495079/
https://www.ncbi.nlm.nih.gov/pubmed/31051334
http://dx.doi.org/10.1016/j.omtn.2019.04.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495079/
https://www.ncbi.nlm.nih.gov/pubmed/31051334
http://dx.doi.org/10.1016/j.omtn.2019.04.002

Ejemplares similares