Nuclear factor‐kappa B‐dependent X‐box binding protein 1 signalling promotes the proliferation of nucleus pulposus cells under tumour necrosis factor alpha stimulation

OBJECTIVES: Tumour necrosis factor alpha (TNF‐α) expressed by nucleus pulposus cells (NPCs) plays a critical role in intervertebral disc (IVD) degeneration. A key unfolded protein response (UPR) component, X‐box binding protein 1 (XBP1) and nuclear factor‐kappa B (NF‐κB) are essential for cell survi...

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Detalles Bibliográficos
Autores principales: Chen, Lu, Xie, Zhi‐Yang, Liu, Lei, Zhu, Lei, Wang, Feng, Fan, Pan, Sinkemani, Arjun, Zhang, Cong, Hong, Xin, Wu, Xiao‐Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496019/
https://www.ncbi.nlm.nih.gov/pubmed/30430692
http://dx.doi.org/10.1111/cpr.12542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496019/
https://www.ncbi.nlm.nih.gov/pubmed/30430692
http://dx.doi.org/10.1111/cpr.12542

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