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Female-biased embryonic death from genomic instability-induced inflammation
Genomic instability (GIN) can trigger cellular responses including checkpoint activation, senescence, and inflammation (1,2). Though extensively studied in cell culture and cancer paradigms, little is known about the impact of GIN during embryonic development, a period of rapid cellular proliferatio...
Autores principales: | McNairn, Adrian J., Chuang, Chen-Hua, Bloom, Jordana C., Wallace, Marsha D., Schimenti, John C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497049/ https://www.ncbi.nlm.nih.gov/pubmed/30787433 http://dx.doi.org/10.1038/s41586-019-0936-6 |
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