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Thermodynamic investigation of DNA-binding affinity of wild-type and mutant transcription factor RUNX1
Transcription factor RUNX1 and its binding partner CBFβ play a critical role in gene regulation for hematopoiesis. Mutations of RUNX1 cause ~10% of acute myeloid leukemia (AML) with a particularly poor prognosis. The current paradigm for the leukemogenesis is that insufficient activity of wild-type...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497270/ https://www.ncbi.nlm.nih.gov/pubmed/31048839 http://dx.doi.org/10.1371/journal.pone.0216203 |