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Thermodynamic investigation of DNA-binding affinity of wild-type and mutant transcription factor RUNX1

Transcription factor RUNX1 and its binding partner CBFβ play a critical role in gene regulation for hematopoiesis. Mutations of RUNX1 cause ~10% of acute myeloid leukemia (AML) with a particularly poor prognosis. The current paradigm for the leukemogenesis is that insufficient activity of wild-type...

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Detalles Bibliográficos
Autores principales:	Wu, Fangrui, Song, Tidie, Yao, Yuan, Song, Yongcheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497270/ https://www.ncbi.nlm.nih.gov/pubmed/31048839 http://dx.doi.org/10.1371/journal.pone.0216203

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