Pretreatment With PCSK9 Inhibitor Protects the Brain Against Cardiac Ischemia/Reperfusion Injury Through a Reduction of Neuronal Inflammation and Amyloid Beta Aggregation

BACKGROUND: Cardiac ischemic/reperfusion (I/R) injury leads to brain damage. A new antihyperlipidemic drug is aimed at inhibiting PCSK9 (proprotein convertase subtilisin/kexin type 9), a molecule first identified in a neuronal apoptosis paradigm. Thus, the PCSK9 inhibitor (PCSK9i) may play a role in...

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Detalles Bibliográficos
Autores principales: Apaijai, Nattayaporn, Moisescu, Dalila Monica, Palee, Siripong, McSweeney, Christian Mervyn, Saiyasit, Napatsorn, Maneechote, Chayodom, Boonnag, Chiraphat, Chattipakorn, Nipon, Chattipakorn, Siriporn C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497363/
https://www.ncbi.nlm.nih.gov/pubmed/30636486
http://dx.doi.org/10.1161/JAHA.118.010838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497363/
https://www.ncbi.nlm.nih.gov/pubmed/30636486
http://dx.doi.org/10.1161/JAHA.118.010838

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