Cargando…
A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels
ASICs are proton-gated sodium channels expressed in neurons. Structures of chicken ASIC1 in three conformations have advanced understanding of proton-mediated gating; however, a molecular mechanism describing desensitization from open and pre-open states (steady-state desensitization or SSD) remains...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497441/ https://www.ncbi.nlm.nih.gov/pubmed/31045491 http://dx.doi.org/10.7554/eLife.45851 |