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A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels

ASICs are proton-gated sodium channels expressed in neurons. Structures of chicken ASIC1 in three conformations have advanced understanding of proton-mediated gating; however, a molecular mechanism describing desensitization from open and pre-open states (steady-state desensitization or SSD) remains...

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Detalles Bibliográficos
Autores principales:	Wu, Yangyu, Chen, Zhuyuan, Canessa, Cecilia M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497441/ https://www.ncbi.nlm.nih.gov/pubmed/31045491 http://dx.doi.org/10.7554/eLife.45851

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