The glutamate release inhibitor riluzole increases DNA damage and enhances cytotoxicity in human glioma cells, in vitro and in vivo

PURPOSE: High-grade gliomas are lethal malignancies that cause morbidity and mortality due to local progression rather than metastatic spread. Our group has previously demonstrated that human GRM1 (hGRM1) is ectopically expressed in melanocytes leading to a transformed phenotype. Riluzole, a glutama...

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Detalles Bibliográficos
Autores principales: Khan, Atif J., LaCava, Stephanie, Mehta, Monal, Schiff, Devora, Thandoni, Aditya, Jhawar, Sachin, Danish, Shabbar, Haffty, Bruce G., Chen, Suzie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497458/
https://www.ncbi.nlm.nih.gov/pubmed/31073373
http://dx.doi.org/10.18632/oncotarget.26854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497458/
https://www.ncbi.nlm.nih.gov/pubmed/31073373
http://dx.doi.org/10.18632/oncotarget.26854

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